{"id":120937,"date":"2023-10-21T10:55:36","date_gmt":"2023-10-21T09:55:36","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=120937"},"modified":"2024-03-20T16:06:31","modified_gmt":"2024-03-20T16:06:31","slug":"mens-biological-clock","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/sv\/mens-biological-clock\/","title":{"rendered":"Har m\u00e4n biologiska klockor? Manlig fertilitet och \u00e5lder"},"content":{"rendered":"

N\u00e4r vi t\u00e4nker p\u00e5 \u00e5lderns inverkan p\u00e5 fertiliteten \u00e4r det ofta kvinnor vi t\u00e4nker p\u00e5, med fokus p\u00e5 minskad \u00e4ggproduktion, kromosomala problem och infertilitet. En studie visade till och med att 1 av 5 m\u00e4n anser att infertilitet bara \u00e4r en kvinnofr\u00e5ga. Men h\u00e4r \u00e4r n\u00e5got som det inte talas om lika ofta - \u00e5lderns inverkan p\u00e5 den manliga fertiliteten. F\u00e5r m\u00e4n n\u00e5gonsin r\u00e5det att \u00e4gna mer uppm\u00e4rksamhet \u00e5t sina biologiska klockor?<\/p>\n

 <\/p>\n

\u00c5ldersfaktorn: F\u00f6rdr\u00f6jning av faderskap<\/h2>\n

F\u00f6rv\u00e5nansv\u00e4rt nog finns det i m\u00e5nga l\u00e4nder inget som avskr\u00e4cker \u00e4ldre m\u00e4n som vill bli pappor, till skillnad fr\u00e5n hur \u00e4ldre kvinnor ofta avr\u00e5ds fr\u00e5n moderskap. National Institute for Clinical Excellence i England och Wales, till exempel, rekommenderar att NHS inte ska erbjuda IVF till kvinnor \u00f6ver 42 \u00e5r<\/a>men det finns inget s\u00e5dant omn\u00e4mnande av faderns \u00e5lder i v\u00e4gledningen. Fr\u00e5gan om vad som anses vara \"gammalt\" i samband med faderskap f\u00f6rblir i stort sett obehandlad.<\/p>\n

Forskning visar dock att m\u00e4ns spermier b\u00f6rjar bli l\u00e5ngsammare runt 40-\u00e5rs\u00e5ldern, vilket g\u00f6r det sv\u00e5rare att bli gravid. Dessutom l\u00f6per barn som f\u00f6ds av \u00e4ldre f\u00e4der en \u00f6kad risk att drabbas av sjukdomar som autism, schizofreni och leukemi.<\/p>\n

I USA \u00e4r trenden att m\u00e4n blir pappor i h\u00f6gre \u00e5ldrar p\u00e5 upp\u00e5tg\u00e5ende. \u00c5r 1980 f\u00f6ddes cirka 43 av 1.000 barn av m\u00e4n i \u00e5ldern 35-49 \u00e5r. \u00c5r 2015 hade denna siffra \u00f6kade till cirka 69 av 1 000 sp\u00e4dbarn<\/a>.<\/p>\n

 <\/p>\n

Varf\u00f6r spermiekvalitet spelar roll: Inverkan av \u00e5lder<\/h2>\n

Faderns \u00e5lder p\u00e5verkar ocks\u00e5 spermiernas kvalitet. En systematisk \u00f6versikt fr\u00e5n 2015, d\u00e4r 90 studier med 93.839 f\u00f6rs\u00f6kspersoner granskades, visade att en mans \u00e5lder har en negativ inverkan p\u00e5 spermiernas kvalitet, bland annat n\u00e4r det g\u00e4ller utseende, r\u00f6rlighet och DNA-skador.<\/p>\n

Spermiekvaliteten spelar en avg\u00f6rande roll f\u00f6r att bli med barn. I en studie som omfattade 2 112 par i Storbritannien visade det sig att m\u00e4n \u00f6ver 45 \u00e5r var n\u00e4stan fem g\u00e5nger mer ben\u00e4gna att ta mer \u00e4n ett \u00e5r p\u00e5 sig att bli gravida j\u00e4mf\u00f6rt med m\u00e4n under 25 \u00e5r, \u00e4ven n\u00e4r den kvinnliga partnern var ung.<\/p>\n

 <\/p>\n

Riskerna med att skaffa barn senare<\/h2>\n

Utfallet av provr\u00f6rsbefruktning (IVF) f\u00f6r \u00e4ldre m\u00e4n verkar ocks\u00e5 vara mindre gynnsamt. I en nyligen genomf\u00f6rd studie, d\u00e4r 11 forskningsrapporter och 10 527 \u00e4ggdonationscykler granskades, konstaterades att stigande \u00e5lder hos m\u00e4n var f\u00f6rknippad med en liten minskning av antalet levande f\u00f6dda.<\/p>\n

Barn som avlats av \u00e4ldre m\u00e4n l\u00f6per ocks\u00e5 h\u00f6gre risk att drabbas av missfall, d\u00f6df\u00f6ddhet och f\u00f6r tidig f\u00f6dsel. Detta belyser missuppfattningen att om spermier kan simma och tr\u00e4nga in i ett \u00e4gg \u00e4r allt bra - en uppfattning som m\u00e5nga, inklusive viss medicinsk personal, \u00e4nnu inte helt har f\u00f6rst\u00e5tt.<\/p>\n

\u00c4ldre pappor l\u00f6per st\u00f6rre risk att f\u00e5 barn med missbildningar, vissa cancerformer och neurologiska sjukdomar. Forskning visar att \u00e4ldre pappor l\u00f6per st\u00f6rre risk att f\u00e5 barn med missbildningar som l\u00e4ppspalt och att de l\u00f6per \u00f6kad risk att drabbas av vissa cancerformer under barndomen.<\/p>\n

S\u00e5 vad ligger bakom den h\u00e4r alarmerande statistiken? Hur kommer det sig att vi ser fler \u00e4ldre pappor i nyheterna, som manliga k\u00e4ndisar som f\u00e5r barn n\u00e4r de \u00e4r 70 och 80 \u00e5r gamla? Anledningen ligger i den kontinuerliga produktionen av spermier under en mans liv. Spermier produceras ungef\u00e4r var 74:e dag, och de tar aldrig slut. Forskning tyder dock p\u00e5 att ju l\u00e4ngre spermieproduktionen p\u00e5g\u00e5r, desto st\u00f6rre \u00e4r sannolikheten f\u00f6r att genetiska mutationer uppst\u00e5r.<\/p>\n

 <\/p>\n

F\u00f6rst\u00e5else f\u00f6r reproduktionsprocessen<\/h2>\n

Spermieproduktionen baseras p\u00e5 spermatogoniala stamceller, som kontinuerligt f\u00f6rnyas genom celldelning. Vid varje replikering finns det dock en risk f\u00f6r kopieringsfel. Ju \u00e4ldre en man \u00e4r, desto fler g\u00e5nger replikerar sig stamcellerna, vilket leder till fler m\u00f6jligheter till misstag. Barn till \u00e4ldre f\u00e4der kommer sannolikt att ha fler genetiska mutationer \u00e4n de som f\u00f6ds av yngre f\u00e4der.<\/p>\n

De flesta av dessa mutationer \u00e4r ofarliga, men vissa kan f\u00e5 allvarliga konsekvenser. De kan bidra till genetiska sjukdomar och drabbar ungef\u00e4r en av 300 levande f\u00f6dda. Dessa \"de novo\"-mutationer ligger bakom olika sjukdomar, bland annat akondroplasi och Apert syndrom.<\/p>\n

Dessutom kan de \u00e5ldersrelaterade f\u00f6r\u00e4ndringarna i epigenetiska m\u00e4rken som finns p\u00e5 DNA i m\u00e4nskliga spermier spela en roll. Dessa epigenetiska markeringar styr genuttrycket och kan f\u00f6r\u00e4ndras p\u00e5 grund av olika milj\u00f6faktorer. Dessa f\u00f6r\u00e4ndringar \u00e4r inte bara relaterade till spermiernas utveckling utan har ocks\u00e5 samband med nervsystemets utveckling, \u00e4ven om de exakta orsakerna fortfarande \u00e4r oklara.<\/p>\n

 <\/p>\n

Faderns \u00e5lder och behovet av medvetenhet<\/h2>\n

Det \u00e4r uppenbart att faderns \u00e5lder har betydelse<\/a>Allt fler m\u00e4n tar p\u00e5 sig faderskapet i h\u00f6gre \u00e5ldrar. En kombination av faktorer, inklusive f\u00f6rsenade \u00e4ktenskap, andra \u00e4ktenskap, assisterad befruktning och f\u00f6r\u00e4ndrade samh\u00e4llsnormer, har lett till att fler m\u00e4n blir \u00e4ldre pappor. Men som vi har sett \u00e4r det inte utan konsekvenser.<\/p>\n

I detta landskap har f\u00f6retag som ExSeed introducerat innovativa l\u00f6sningar f\u00f6r att hj\u00e4lpa m\u00e4n att bed\u00f6ma och \u00f6vervaka sin fertilitet bekv\u00e4mt hemifr\u00e5n. Det ExSeed spermietest i hemmet<\/a>kombinerat med en smartphone-app ger m\u00e4n m\u00f6jlighet att m\u00e4ta sina spermiers r\u00f6rlighet, koncentration och \u00f6vergripande kvalitet, allt i bekv\u00e4mligheten av sitt eget utrymme. Detta ger m\u00e4nnen m\u00f6jlighet att ta kontroll \u00f6ver sin reproduktiva h\u00e4lsa.<\/p>","protected":false},"excerpt":{"rendered":"

When we think of the effects of age on fertility, our minds often gravitate towards women, focusing on the declining egg supply, chromosomal issues, and infertility. One study even found that 1 in 5 men consider infertility to be only a woman’s issue. But here’s something that’s not talked about as often \u2013 the impact […]<\/p>\n","protected":false},"author":3,"featured_media":126791,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[198,201],"tags":[],"class_list":["post-120937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mens-fertility","category-mind-body"],"acf":[],"yoast_head":"\nDo Men Have Biological Clocks? 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