{"id":117593,"date":"2023-09-07T10:49:09","date_gmt":"2023-09-07T09:49:09","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=117593"},"modified":"2024-04-03T16:19:34","modified_gmt":"2024-04-03T15:19:34","slug":"first-model-human-embryo-without-egg-or-sperm","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/sv\/first-model-human-embryo-without-egg-or-sperm\/","title":{"rendered":"Forskare utvecklar modell av m\u00e4nskligt embryo utan \u00e4gg eller spermier"},"content":{"rendered":"<p>I en banbrytande prestation har forskare vid <a href=\"https:\/\/wis-wander.weizmann.ac.il\/life-sciences\/human-embryo-models-grown-stem-cells\">Weizmann-institutet<\/a> har lyckats odla fram en enhet som p\u00e5minner mycket om ett tidigt m\u00e4nskligt embryo, helt utan spermier, \u00e4gg eller livmoder. Denna \"embryomodell\" som skapats med hj\u00e4lp av stamceller har en sl\u00e5ende likhet med ett riktigt 14 dagar gammalt m\u00e4nskligt embryo och fris\u00e4tter till och med hormoner som kan utl\u00f6sa ett positivt graviditetstest i laboratoriemilj\u00f6.<\/p>\n<h2>Varf\u00f6r embryomodeller \u00e4r viktiga<\/h2>\n<p>Att f\u00f6rst\u00e5 de f\u00f6rsta veckorna efter befruktningen, fr\u00e5n en samling odifferentierade celler till utvecklingen av igenk\u00e4nnbara strukturer, \u00e4r avg\u00f6rande. Denna period pr\u00e4glas av snabba f\u00f6r\u00e4ndringar och \u00e4r en betydande k\u00e4lla till missfall och fosterskador, men den \u00e4r fortfarande d\u00e5ligt f\u00f6rst\u00e5dd.<\/p>\n<p>Embryoforskning har l\u00e4nge varit ett komplext och etiskt k\u00e4nsligt omr\u00e5de. Forskare utforskar nu emellertid innovativa metoder f\u00f6r att \u00e5terskapa naturlig embryoutveckling. Denna nya studie, som publicerades i tidskriften <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06604-5\">Natur<\/a>utg\u00f6r en viktig milstolpe - skapandet av en \"komplett\" embryomodell som troget \u00e5terskapar viktiga tidiga embryostrukturer.<\/p>\n<h2>Hur gjorde de det?<\/h2>\n<p>I st\u00e4llet f\u00f6r att anv\u00e4nda traditionella spermier och \u00e4gg anv\u00e4nde forskarna naiva stamceller som omprogrammerades till att ha potential att utvecklas till alla typer av v\u00e4vnader i m\u00e4nniskokroppen. Dessa stamceller \u00f6vertalades sedan att utvecklas till fyra specifika celltyper som finns i tidiga m\u00e4nskliga embryon:<\/p>\n<ol>\n<li>Epiblastceller, som s\u00e5 sm\u00e5ningom bildar embryot eller fostret.<\/li>\n<li>Trofoblastceller, ansvariga f\u00f6r placentans utveckling.<\/li>\n<li>Hypoblastceller, som bidrar till gules\u00e4cken.<\/li>\n<li>Extraembryonala mesodermceller.<\/li>\n<\/ol>\n<p>Dessa olika celltyper, totalt 120 celler, kombinerades i exakta proportioner, och forskarna observerade det anm\u00e4rkningsv\u00e4rda fenomenet att cirka 1% av dessa celler spontant satte ihop sig till en struktur som liknade ett m\u00e4nskligt embryo.<\/p>\n<h2>En lovande framtid<\/h2>\n<p>\u00c4ven om detta \u00e4r ett banbrytande resultat v\u00e4cker det viktiga etiska fr\u00e5gor, s\u00e4rskilt som dessa embryomodeller ligger n\u00e4ra de verkliga embryonas utvecklingsstadier. F\u00f6rhoppningen \u00e4r att dessa modeller ska hj\u00e4lpa forskarna att f\u00e5 insikter i hur olika celltyper uppst\u00e5r, de inledande stadierna av organutveckling och f\u00f6rst\u00e5elsen av \u00e4rftliga eller genetiska sjukdomar.<\/p>\n<p>Dessutom finns det potential att f\u00f6rb\u00e4ttra IVF-resultaten (in vitro fertilisering) genom att unders\u00f6ka varf\u00f6r vissa embryon inte utvecklas eller genom att anv\u00e4nda modellerna f\u00f6r att testa l\u00e4kemedlens s\u00e4kerhet under graviditeten.<\/p>\n<h2>V\u00e4gen fram\u00e5t<\/h2>\n<p>\u00c4ven om denna studie \u00e4r ett betydande steg fram\u00e5t \u00e4r det viktigt att ta itu med den nuvarande 99%-misslyckandefrekvensen vid montering av dessa embryomodeller. Att uppn\u00e5 mer konsekventa resultat kommer att vara avg\u00f6rande f\u00f6r att f\u00f6rst\u00e5 missfall och infertilitet fullt ut.<\/p>\n<p>N\u00e4r dessa modeller n\u00e4rmar sig verkliga embryon v\u00e4cker de dessutom komplexa etiska fr\u00e5gor. B\u00f6r de regleras p\u00e5 samma s\u00e4tt som m\u00e4nskliga embryon, eller \u00e4r en mer avslappnad inst\u00e4llning acceptabel? Det \u00e4r ett \u00e4mne som sannolikt kommer att ge upphov till en omfattande debatt.<\/p>\n<p>Sammanfattningsvis utg\u00f6r denna forskning en anm\u00e4rkningsv\u00e4rd milstolpe inom embryoutvecklingen. Den erbjuder en lovande v\u00e4g f\u00f6r att studera de invecklade h\u00e4ndelser som leder till att m\u00e4nniskokroppen bildas, och kastar ljus \u00f6ver en tidigare g\u00e5tfull period av m\u00e4nniskans utveckling. Och i den anda som pr\u00e4glar vetenskapliga framsteg uppmuntrar det oss att forts\u00e4tta utforska gr\u00e4nserna f\u00f6r v\u00e5r f\u00f6rst\u00e5else av livet sj\u00e4lvt.<\/p>\n<p>&nbsp;<\/p>\n<p>Vill du f\u00f6rst\u00e5 och f\u00f6rb\u00e4ttra din manliga fertilitet? F\u00e5 m\u00e4nniskor inser att 40% av infertiliteterna beror p\u00e5 den manliga faktorn! P\u00e5 <a href=\"https:\/\/www.exseedhealth.com\/sv\/\">ExSeed<\/a> Vi har utvecklat ett spermatestkit f\u00f6r hemmabruk som ger dig m\u00f6jlighet att se dina spermier under mikroskop och f\u00e5 reda p\u00e5 ditt totala antal r\u00f6rliga spermier, allt i bekv\u00e4mligheten av ditt eget hem. L\u00e4s mer om v\u00e5rt <a href=\"https:\/\/www.exseedhealth.com\/sv\/exseed-home-sperm-test\/\">ExSeed Spermatest<\/a> h\u00e4r.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a ground-breaking achievement, scientists at the Weizmann Institute have successfully grown an entity that closely mimics an early human embryo, all without the use of sperm, eggs, or a womb. This &#8220;embryo model&#8221; created using stem cells bears a striking resemblance to a real 14-day-old human embryo and even releases hormones capable of triggering [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":124590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[203,198],"tags":[],"class_list":["post-117593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-community","category-mens-fertility"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>First Model Human Embryo Made Without Sperm or Egg<\/title>\n<meta name=\"description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/sv\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Model Human Embryo Made Without Sperm or Egg\" \/>\n<meta property=\"og:description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.exseedhealth.com\/sv\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:site_name\" content=\"ExSeed Health\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ExSeedHealth\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-07T09:49:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-03T15:19:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.exseedhealth.com\/wp-content\/uploads\/2023\/09\/sperm-volume-1920x1080-1-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Emil Andersen, PhD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:site\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:label1\" content=\"Skriven av\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emil Andersen, PhD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Ber\u00e4knad l\u00e4stid\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\"},\"author\":{\"name\":\"Emil Andersen, PhD\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#\\\/schema\\\/person\\\/5d08eb43d90734a01dcf3cb77ce5e109\"},\"headline\":\"Scientists Develop Model Human Embryo Without Egg or Sperm\",\"datePublished\":\"2023-09-07T09:49:09+00:00\",\"dateModified\":\"2024-04-03T15:19:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\"},\"wordCount\":584,\"publisher\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.exseedhealth.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/sperm-volume-1920x1080-1-1.jpg\",\"articleSection\":[\"Community\",\"Men\u2019s Fertility\"],\"inLanguage\":\"sv-SE\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\",\"url\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\",\"name\":\"First Model Human Embryo Made Without Sperm or Egg\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.exseedhealth.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/sperm-volume-1920x1080-1-1.jpg\",\"datePublished\":\"2023-09-07T09:49:09+00:00\",\"dateModified\":\"2024-04-03T15:19:34+00:00\",\"description\":\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. 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He is renowned for being the lead author of the most extensive study to date on the impact of weight loss on semen quality. During his tenure at the University of Cambridge, Emil spearheaded innovative research focused on deciphering the fundamental mechanisms of sperm and developing methods to assess their fertility potential. His contributions to the field are widely recognized, with multiple publications in esteemed peer-reviewed scientific journals.\",\"url\":\"https:\\\/\\\/www.exseedhealth.com\\\/sv\\\/author\\\/ea\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"F\u00f6rsta modellen av m\u00e4nskligt embryo tillverkat utan spermier eller \u00e4gg","description":"Dessa fullt utvecklade syntetiska modeller, som motsvarar ett dag 14-embryo, kan bana v\u00e4g f\u00f6r nya unders\u00f6kningar inom infertilitet. 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Han \u00e4r k\u00e4nd f\u00f6r att vara huvudf\u00f6rfattare till den hittills mest omfattande studien om hur viktminskning p\u00e5verkar spermakvaliteten. Under sin tid vid University of Cambridge stod Emil i spetsen f\u00f6r innovativ forskning med fokus p\u00e5 att dechiffrera de grundl\u00e4ggande mekanismerna f\u00f6r spermier och utveckla metoder f\u00f6r att bed\u00f6ma deras fertilitetspotential. 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