{"id":101943,"date":"2023-03-14T16:18:58","date_gmt":"2023-03-14T16:18:58","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=101943"},"modified":"2024-03-21T10:56:40","modified_gmt":"2024-03-21T10:56:40","slug":"cystic-fibrosis-male-fertility","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/sv\/cystic-fibrosis-male-fertility\/","title":{"rendered":"Cystisk fibros och manlig fertilitet"},"content":{"rendered":"<p>Cystisk fibros \u00e4r ett tillst\u00e5nd som drabbar cirka 100 000 m\u00e4nniskor runt om i v\u00e4rlden - och 50% av dessa \u00e4r m\u00e4n. Tillst\u00e5ndet har l\u00e5ngtg\u00e5ende effekter p\u00e5 h\u00e4lsan och livsstilen hos de m\u00e4nniskor som lider av det - men kan det p\u00e5verka din fertilitet?<\/p>\n<p>&nbsp;<\/p>\n<h2>Vad \u00e4r cystisk fibros?<\/h2>\n<p>Cystisk fibros (ibland kallat CF) \u00e4r ett medicinskt tillst\u00e5nd som leder till allvarliga skador p\u00e5 lungorna samt p\u00e5verkar matsm\u00e4ltningssystemet och andra organ i kroppen. Sjukdomen p\u00e5verkar produktionen av slem, svett och matsm\u00e4ltningssafter i magen.<\/p>\n<p>F\u00f6r personer utan CF \u00e4r dessa v\u00e4tskor vanligtvis tunna och hala. Personer med cystisk fibros har dock en defekt gen som g\u00f6r att dessa v\u00e4tskor blir tjocka och klibbiga. Detta leder till att slem ansamlas i lungorna och bukspottk\u00f6rteln och att r\u00f6r, kanaler och g\u00e5ngar t\u00e4pps till. Detta g\u00f6r det sv\u00e5rt f\u00f6r dem att andas och p\u00e5verkar \u00e4ven andra kroppsfunktioner.<\/p>\n<p>Andningsproblem orsakas av slembildning i lungorna, och personer med CF upplever ofta att de har andn\u00f6d och k\u00e4mpar med \u00e5terkommande br\u00f6stinfektioner. Personer med CF har ocks\u00e5 ofta olika matsm\u00e4ltningsproblem - detta beror p\u00e5 att slem ocks\u00e5 t\u00e4pper till bukspottk\u00f6rteln och hindrar enzymer som beh\u00f6vs f\u00f6r en korrekt matsm\u00e4ltning fr\u00e5n att n\u00e5 tarmen.<\/p>\n<p>Personer med CF har tyv\u00e4rr en l\u00e4gre f\u00f6rv\u00e4ntad livsl\u00e4ngd, men tack vare medicinska framsteg lever de l\u00e4ngre och vissa lyckas leva ett relativt normalt liv - \u00e4ven om de kr\u00e4ver daglig v\u00e5rd och regelbunden omsorg och medicinska insatser.<\/p>\n<p>&nbsp;<\/p>\n<h2>\u00c4r cystisk fibros \u00e4rftligt?<\/h2>\n<p>Cystisk fibros \u00e4r en \u00e4rftlig sjukdom som orsakas av en defekt gen som p\u00e5verkar hur salt och vatten r\u00f6r sig in och ut ur cellerna. Man kan inte \"f\u00e5\" cystisk fibros utan f\u00f6ds med sjukdomen om b\u00e5da f\u00f6r\u00e4ldrarna \u00e4r b\u00e4rare av den defekta genen.<\/p>\n<p>Det uppskattas att 1 av 25 personer i Storbritannien \u00e4r b\u00e4rare av den recessiva CF-genen. Det betyder inte n\u00f6dv\u00e4ndigtvis att en f\u00f6r\u00e4lder sj\u00e4lv kommer att ha cystisk fibros.<\/p>\n<p>Om b\u00e5da f\u00f6r\u00e4ldrarna \u00e4r b\u00e4rare av anlaget finns det en:<\/p>\n<ul>\n<li>En 50%-risk att barnet \u00e4rver en felaktig gen fr\u00e5n en f\u00f6r\u00e4lder och blir b\u00e4rare av genen<\/li>\n<li>En 25% chans att barnet inte \u00e4rver n\u00e5gra felaktiga gener och inte f\u00e5r cystisk fibros eller kan f\u00f6ra den vidare<\/li>\n<li>En 25%-risk att barnet \u00e4rver den felaktiga genen fr\u00e5n b\u00e5da f\u00f6r\u00e4ldrarna och sj\u00e4lv f\u00e5r cystisk fibros<\/li>\n<\/ul>\n<p>Om en f\u00f6r\u00e4lder har cystisk fibros och den andra \u00e4r b\u00e4rare, finns det en:<\/p>\n<ul>\n<li>50% chans att barnet kommer att vara b\u00e4rare av den felaktiga genen men inte ha tillst\u00e5ndet<\/li>\n<li>50% chans att barnet kommer att ha cystisk fibros<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>P\u00e5verkar cystisk fibros fertiliteten hos kvinnor?<\/h2>\n<p>Generellt sett \u00e4r kvinnor med CF fortfarande fertila och de allra flesta kan bli gravida p\u00e5 naturlig v\u00e4g efter 12 m\u00e5naders f\u00f6rs\u00f6k. Det finns dock ett par biverkningar av sjukdomen som kan g\u00f6ra det lite sv\u00e5rare.<\/p>\n<p>F\u00f6r det f\u00f6rsta \u00e4r deras livmoderslem ofta tjockare \u00e4n slemmet hos n\u00e5gon som inte har tillst\u00e5ndet. Livmoderhalssekretet spelar en viktig roll n\u00e4r det g\u00e4ller att hj\u00e4lpa spermierna att simma mot \u00e4gget, och n\u00e4r det \u00e4r tjockt och klibbigt kan det g\u00f6ra det sv\u00e5rare f\u00f6r dem att ta sig dit!<\/p>\n<p>De matsm\u00e4ltningsproblem som \u00e4r f\u00f6rknippade med CF kan ocks\u00e5 orsaka problem med \u00e4gglossningen, och vissa kvinnor med CF m\u00e4rker att de har oregelbundna menstruationscykler.<\/p>\n<p>\u00c4ven om dessa tv\u00e5 faktorer kan bidra till en sv\u00e5rare TTC-resa \u00e4r det fortfarande definitivt m\u00f6jligt att bli gravid och f\u00f6da ett friskt barn om du har cystisk fibros. Yorus medicinska team och fertilitetsspecialister kommer att kunna ge dig r\u00e5d om den b\u00e4sta handlingsplanen om du k\u00e4mpar.<\/p>\n<p>&nbsp;<\/p>\n<h2>P\u00e5verkar cystisk fibros fertiliteten hos m\u00e4n?<\/h2>\n<p>Tyv\u00e4rr \u00e4r fr\u00e5gorna kring cystisk fibros och fertilitet mer komplexa f\u00f6r m\u00e4n. \u00d6ver <a href=\"https:\/\/www.cff.org\/managing-cf\/fertility-men-cf\">97% av m\u00e4n<\/a> med cystisk fibros klassas som infertila - \u00e4ven om <a href=\"https:\/\/www.cff.org\/managing-cf\/fertility-men-cf\">90%<\/a> av dem kan producera friska spermier. S\u00e5 vad \u00e4r det som orsakar fertilitetsproblemen?<\/p>\n<p>Infertilitet hos m\u00e4n med cystisk fibros beror n\u00e4stan alltid p\u00e5 en brist p\u00e5 en viktig del av det manliga reproduktionssystemet - Vas Deferens. Vas deferens \u00e4r en l\u00e5ng kanal som f\u00f6rbinder bitestiklarna (ett spiralformat r\u00f6r som lagrar spermier efter att de har producerats i testiklarna) med b\u00e4ckenh\u00e5lan. Vas deferens har till uppgift att transportera mogna spermier fr\u00e5n bitestiklarna till urinr\u00f6ret inf\u00f6r utl\u00f6sningen.<\/p>\n<p>Om du inte har n\u00e5gon s\u00e4desledare har du sannolikt ett tillst\u00e5nd som kallas medf\u00f6dd bilateral avsaknad av s\u00e4desledare (CBAVD). Detta \u00e4r extremt vanligt hos m\u00e4n med cystisk fibros. Om du har CBAVD, \u00e4ven om du producerar friska spermier, finns det inget s\u00e4tt f\u00f6r dem att ta sig in i ditt ejakulat, vilket inneb\u00e4r att det inte finns n\u00e5gra spermier i ditt spermaprov (och inga spermier som kan befrukta ett \u00e4gg under sex).<\/p>\n<p>&nbsp;<\/p>\n<h2>Alternativ f\u00f6r fertilitetsbehandling f\u00f6r m\u00e4n med cystisk fibros<\/h2>\n<p>Att inte ha n\u00e5gra spermier i sperman kommer naturligtvis att g\u00f6ra fertilitetsresan sv\u00e5rare. Men den goda nyheten \u00e4r att om du producerar friska spermier \u00e4r det m\u00f6jligt att f\u00e5 egna biologiska barn - du beh\u00f6ver bara en hj\u00e4lpande hand.<\/p>\n<p>Genom kirurgisk spermieextraktion kan spermier avl\u00e4gsnas fr\u00e5n testiklarna eller bitestiklarna och dessa spermier kan anv\u00e4ndas vid assisterad befruktning, t.ex. ICSI och IVF.<\/p>\n<p>Det finns olika kirurgiska alternativ f\u00f6r att utvinna spermier, bl.a.<\/p>\n<p>MESA - mikrokirurgisk aspiration av bitestikelsperma. Operation som utf\u00f6rs under narkos f\u00f6r att avl\u00e4gsna spermier direkt fr\u00e5n bitestiklarna.<br \/>\nPESA - Percutaneous Epididymal Sperm Aspiration - liknar MESA men \u00e4r mindre komplicerat och billigare, en n\u00e5l anv\u00e4nds f\u00f6r att extrahera spermierna s\u00e5 det kan g\u00f6ras under lokalbed\u00f6vning.<br \/>\nTESE - Testicular Sperm Extraction - Operation d\u00e4r v\u00e4vnad tas direkt fr\u00e5n testiklarna och spermier extraheras.<br \/>\nTESA - Testicular Sperm Aspiration - liknar TESE men g\u00f6rs med en n\u00e5l, vilket \u00e4r mindre integritetskr\u00e4nkande och kan g\u00f6ras under lokalbed\u00f6vning.<\/p>\n<p>Om friska spermier hittas under n\u00e5gon av ovanst\u00e5ende procedurer kan de anv\u00e4ndas i fertilitetsbehandlingar och du \u00e4r ett steg n\u00e4rmare att bilda familj.<\/p>\n<p>&nbsp;<\/p>\n<h2>Vad h\u00e4nder om jag \u00e4r b\u00e4rare av CF-gener? Kommer detta att p\u00e5verka min fertilitet?<\/h2>\n<p>Om du \u00e4r b\u00e4rare av den muterade gen som orsakar cystisk fibros finns det en risk att din fertilitet kan p\u00e5verkas - \u00e4ven om du inte har n\u00e5gra andra symtom p\u00e5 sjukdomen. <a href=\"https:\/\/www.fertstert.org\/article\/S0015-0282(10)00308-0\/\">Forskning<\/a> har visat att m\u00e4n med tillst\u00e5ndet azoospermi (inga spermier i s\u00e4desv\u00e4tskan) l\u00f6per dubbelt s\u00e5 stor risk att vara b\u00e4rare av den muterade CF-genen. Vissa m\u00e4n som b\u00e4r p\u00e5 denna recessiva gen kan ocks\u00e5 ha CBAVD (ingen Vas Deferens).<\/p>\n<p>D\u00e4rf\u00f6r, om du uppt\u00e4cker att du har <a href=\"https:\/\/www.exseedhealth.com\/sv\/what-is-azoospermia\/\">Azoospermi<\/a>\u00e4r det tillr\u00e5dligt att l\u00e5ta testa sig f\u00f6r CF-genen. P\u00e5 samma s\u00e4tt, om du uppt\u00e4cker att du \u00e4r b\u00e4rare av CF-genen, b\u00f6r du definitivt unders\u00f6ka om du kan f\u00e5 dina spermier testade. M\u00e5nga m\u00e4nniskor visar inga yttre tecken p\u00e5 azoospermi och uppt\u00e4cker f\u00f6rst att de inte har n\u00e5gra spermier i sitt ejekulat n\u00e4r de b\u00f6rjar f\u00f6rs\u00f6ka f\u00e5 barn.<\/p>\n<p>Om du vill ta ett proaktivt grepp om din h\u00e4lsa och fertilitet kan v\u00e5rt spermietest f\u00f6r hemmabruk hj\u00e4lpa dig. L\u00e4s mer om v\u00e5rt <a href=\"https:\/\/www.exseedhealth.com\/sv\/exseed-home-sperm-test\/\">fertilitetstest f\u00f6r m\u00e4n<\/a> och f\u00e5 reda p\u00e5 ditt totala antal r\u00f6rliga spermier.<\/p>","protected":false},"excerpt":{"rendered":"<p>Cystic Fibrosis is a condition that affects around 100,000 people around the world &#8211; and 50% of those are men. The condition has far reaching effects on the health and lifestyle of people who suffer from it &#8211; but can it affect your fertility? &nbsp; What is Cystic Fibrosis? Cystic Fibrosis (sometimes known as CF) [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":101945,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[198,202],"tags":[],"class_list":["post-101943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mens-fertility","category-womens-fertility"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cystic Fibrosis and Male Fertility<\/title>\n<meta name=\"description\" content=\"Cystic Fibrosis often affects men&#039;s ability to reproduce naturally, thankfully there are methods to overcome apparent infertility, read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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