{"id":82138,"date":"2021-07-20T08:36:23","date_gmt":"2021-07-20T08:36:23","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=82138"},"modified":"2024-10-03T10:32:47","modified_gmt":"2024-10-03T09:32:47","slug":"sperm-dna-damage-and-male-fertility","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/pl\/sperm-dna-damage-and-male-fertility\/","title":{"rendered":"Uszkodzenia DNA plemnik\u00f3w zapewniaj\u0105 wgl\u0105d w m\u0119sk\u0105 p\u0142odno\u015b\u0107"},"content":{"rendered":"<h2><strong>Go\u015bcinny blog profesor Sheeny Lewis z <a href=\"https:\/\/examenlab.com\/\">Examenlab.com<\/a><\/strong><\/h2>\n<p><span data-contrast=\"auto\">Mo\u017cesz by\u0107 zaskoczony - lub by\u0107 mo\u017ce uspokojony - gdy dowiesz si\u0119, \u017ce ponad jedna czwarta par poddaj\u0105cych si\u0119 badaniom p\u0142odno\u015bci otrzymuje informacj\u0119, \u017ce \u017cadna z nich nie ma \u017cadnych wykrywalnych problem\u00f3w <a href=\"https:\/\/www.nhs.uk\/conditions\/infertility\/causes\/\">(1)<\/a>.<\/span><span data-contrast=\"auto\"> Jest to frustruj\u0105ce zar\u00f3wno dla ekspert\u00f3w ds. p\u0142odno\u015bci, jak i dla par desperacko staraj\u0105cych si\u0119 o dziecko. Kt\u00f3ra \u015bcie\u017cka poprowadzi ich we w\u0142a\u015bciwym kierunku? Sk\u0105d maj\u0105 wiedzie\u0107, od czego zacz\u0105\u0107? Skuteczne radzenie sobie z niep\u0142odno\u015bci\u0105 mo\u017ce rozpocz\u0105\u0107 si\u0119 tylko wtedy, gdy zrozumiemy jej g\u0142\u00f3wne przyczyny.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b><span data-contrast=\"auto\">Jako\u015b\u0107 nasienia ponad ilo\u015b\u0107<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">W 2018 r. brytyjski urz\u0105d ds. zap\u0142odnienia i embriologii (Human Fertilization and Embryology Authority) poinformowa\u0142, \u017ce najcz\u0119stszym powodem leczenia niep\u0142odno\u015bci s\u0105 problemy z p\u0142odno\u015bci\u0105 u m\u0119\u017cczyzn <a href=\"https:\/\/www.hfea.gov.uk\/media\/3188\/hfea-fertility-trends-and-figures-2014-2016.pdf\">(2)<\/a><\/span><span data-contrast=\"auto\">\u00a0wi\u0119c\u00a0<\/span><b><span data-contrast=\"auto\">M\u0119\u017cczy\u017ani powinni zosta\u0107 bardzo dok\u0142adnie sprawdzeni<\/span><\/b><span data-contrast=\"auto\">. Zadziwiaj\u0105ce jest to, \u017ce kiedy w ko\u0144cu bada si\u0119 m\u0119sk\u0105 p\u0142odno\u015b\u0107 (jest to zawsze drugorz\u0119dne w stosunku do bada\u0144 kobiet), nacisk k\u0142adzie si\u0119 na analiz\u0119 nasienia i plemnik\u00f3w.\u00a0<\/span><b><i><span data-contrast=\"auto\">ilo\u015b\u0107<\/span><\/i><\/b><span data-contrast=\"auto\">\u00a0nad\u00a0<\/span><b><i><span data-contrast=\"auto\">jako\u015b\u0107<\/span><\/i><\/b><span data-contrast=\"auto\">! A kiedy m\u0119\u017cczy\u017ani maj\u0105\u00a0<\/span><b><span data-contrast=\"auto\">normalny\u00a0<\/span><\/b><span data-contrast=\"auto\">analizy nasienia, s\u0105 one wysoce\u00a0<\/span><span data-contrast=\"auto\">ma\u0142o prawdopodobne<\/span><span data-contrast=\"auto\">\u00a0do dalszego badania. Przy pozornie braku oczywistej przyczyny ich problem\u00f3w z p\u0142odno\u015bci\u0105, badanie m\u0119skiej p\u0142odno\u015bci zatrzymuje si\u0119 w\u0142a\u015bnie w tym miejscu, a uwaga jest kierowana z powrotem na kobiet\u0119.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Istotnym, ale brakuj\u0105cym elementem standardowego procesu badania p\u0142odno\u015bci u par jest\u00a0<\/span><b><span data-contrast=\"auto\">zdrowie plemnik\u00f3w<\/span><\/b><span data-contrast=\"auto\">. Badania wykaza\u0142y, \u017ce 20-40 % m\u0119\u017cczyzn z \"niewyja\u015bnion\u0105\" niep\u0142odno\u015bci\u0105 ma wysokie uszkodzenia DNA (lub fragmentacj\u0119) w spermie <a href=\"https:\/\/doi.org\/10.1093\/humrep\/del326\">(3)<\/a> <a href=\"https:\/\/academic.oup.com\/humrep\/article\/34\/10\/1915\/5581560\">(4)<\/a><\/span><span data-contrast=\"auto\"> i wykazano, \u017ce ma to silny zwi\u0105zek z poronieniem, a tak\u017ce prawdopodobie\u0144stwem powodzenia wspomaganego rozrodu (ART). <a href=\"https:\/\/www.rbmojournal.com\/article\/S1472-6483(12)00590-1\/fulltext\">(5)<\/a><\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Jako\u015b\u0107 DNA plemnika ma kluczowe znaczenie, poniewa\u017c zawiera on kopi\u0119 gen\u00f3w, kt\u00f3re m\u0119\u017cczyzna przekazuje swojemu dziecku. Geny te nie tylko przekazuj\u0105 cechy takie jak kolor oczu czy wzrost, ale tak\u017ce buduj\u0105 nasz m\u00f3zg i determinuj\u0105 nasze zachowanie i przysz\u0142e zdrowie.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b><span data-contrast=\"auto\">Oto odpowiedzi na kilka cz\u0119sto zadawanych nam pyta\u0144, aby pom\u00f3c wszystkim m\u0119\u017cczyznom i ich partnerkom czytaj\u0105cym nasz post:<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2><b><span data-contrast=\"auto\">Po co bada\u0107 DNA plemnik\u00f3w?<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Chocia\u017c uszkodzenie DNA plemnik\u00f3w jest g\u0142\u00f3wn\u0105 przyczyn\u0105 niep\u0142odno\u015bci m\u0119skiej, nie jest ono rutynowo badane w wi\u0119kszo\u015bci klinik. Nawet je\u015bli wyniki badania nasienia s\u0105 prawid\u0142owe, uszkodzenia DNA plemnik\u00f3w mog\u0105 by\u0107 wysokie. Zmniejsza to prawdopodobie\u0144stwo zaj\u015bcia w ci\u0105\u017c\u0119 w spos\u00f3b naturalny, a nawet przy zastosowaniu leczenia <a href=\"https:\/\/www.rbmojournal.com\/article\/S1472-6483(13)00363-5\/fulltext\">(6)<\/a><\/span><span data-contrast=\"auto\">. M\u0119\u017cczy\u017ani z wysokim poziomem uszkodzonego DNA plemnik\u00f3w maj\u0105 r\u00f3wnie\u017c dwukrotnie wi\u0119ksze ryzyko poronienia<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">DNA plemnik\u00f3w jest nie tylko cz\u0119\u015bci\u0105 planu rozwoju dziecka, ale jako\u015b\u0107 DNA plemnik\u00f3w pomo\u017ce ekspertom ds. p\u0142odno\u015bci przewidzie\u0107 leczenie niep\u0142odno\u015bci o najwy\u017cszym prawdopodobie\u0144stwie powodzenia. Oznacza to, \u017ce mo\u017cesz potencjalnie zwi\u0119kszy\u0107 swoje szanse na zaj\u015bcie w ci\u0105\u017c\u0119 przy mniejszej liczbie cykli leczenia.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Zmiany stylu \u017cycia i interwencje kliniczne mog\u0105 poprawi\u0107 uszkodzenia DNA plemnik\u00f3w.\u00a0<\/span><\/b><span data-contrast=\"auto\">\u00a0Pomiar i zrozumienie poziom\u00f3w fragmentacji DNA plemnik\u00f3w jest tak wa\u017cne, aby pom\u00f3c wi\u0119kszej liczbie m\u0119\u017cczyzn zosta\u0107 ojcami.  Niekt\u00f3re uszkodzenia DNA plemnik\u00f3w powstaj\u0105 podczas ich wytwarzania; poprzez zerwanie niekt\u00f3rych nici DNA. Nie mo\u017cna temu zapobiec, ale\u00a0<\/span><b><span data-contrast=\"auto\">m\u0119\u017cczy\u017ani maj\u0105 mo\u017cliwo\u015b\u0107 zmniejszenia uszkodze\u0144 DNA spowodowanych zagro\u017ceniami zwi\u0105zanymi ze stylem \u017cycia, takimi jak palenie tytoniu lub nadwaga<\/span><\/b><span data-contrast=\"auto\">. Dzi\u0119ki odpowiedniemu zrozumieniu i poradom m\u0119\u017cczy\u017ani mog\u0105 chroni\u0107 i poprawia\u0107 zdrowie swoich plemnik\u00f3w.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b><span data-contrast=\"auto\">Gdzie mo\u017cna si\u0119 przebada\u0107?<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><a href=\"https:\/\/examenlab.com\/\"><span data-contrast=\"none\">Examen<\/span><\/a><span data-contrast=\"none\">'s<\/span><span data-contrast=\"auto\"> Dok\u0142adne testy DNA plemnik\u00f3w, oparte na ponad 25 latach bada\u0144 nad p\u0142odno\u015bci\u0105, mierz\u0105 poziom uszkodze\u0144 DNA w plemnikach (wyniki testu w ci\u0105gu zaledwie 10 dni). Test pozwoli Tobie i Twojemu specjali\u015bcie ds. p\u0142odno\u015bci lepiej zrozumie\u0107 jako\u015b\u0107 nasienia i najlepszy dla Ciebie spos\u00f3b leczenia.<\/span><\/p>\n<p><span data-contrast=\"auto\">Testy Exact s\u0105 dost\u0119pne w wi\u0119kszo\u015bci klinik leczenia niep\u0142odno\u015bci w Wielkiej Brytanii i cieszymy si\u0119, \u017ce rozszerzamy dost\u0119p do nich w Europie. ExSeed Health, Examen i klinika p\u0142odno\u015bci Skive w Danii wsp\u00f3\u0142pracuj\u0105 w ramach projektu badawczego maj\u0105cego na celu zmierzenie poprawy s\u0142abej jako\u015bci nasienia poprzez interwencje zwi\u0105zane ze stylem \u017cycia.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<blockquote><p><b><span data-contrast=\"auto\">PROJEKT I CEL:<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Ocena wp\u0142ywu programu multimodalnego stylu \u017cycia na jako\u015b\u0107 nasienia i fragmentacj\u0119 DNA u m\u0119\u017cczyzn poddawanych leczeniu niep\u0142odno\u015bci.<\/span><\/b><span data-ccp-props=\"{&quot;335551550&quot;:2,&quot;335551620&quot;:2}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Uwa\u017ca si\u0119, \u017ce obni\u017cona jako\u015b\u0107 spermy i uszkodzenia DNA w plemnikach powoduj\u0105 obni\u017con\u0105 p\u0142odno\u015b\u0107 u oko\u0142o 40% niep\u0142odnych par. Opr\u00f3cz obni\u017conej p\u0142odno\u015bci, uszkodzenie DNA plemnik\u00f3w cz\u0119sto przyczynia si\u0119 do zwi\u0119kszonej liczby mutacji punktowych u p\u0142odu i dziecka. Mo\u017ce to skutkowa\u0107 spontanicznymi poronieniami, wadami wrodzonymi lub chorobami u dzieci i m\u0142odzie\u017cy, takimi jak autyzm i schizofrenia. Dzi\u0119ki temu projektowi s\u0142aba jako\u015b\u0107 nasienia ma zosta\u0107 poprawiona za pomoc\u0105 spersonalizowanych wskaz\u00f3wek ExSeed dotycz\u0105cych stylu \u017cycia. Oczekuje si\u0119, \u017ce projekt zostanie sfinalizowany w 4. kwartale 2021 roku.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><\/blockquote>\n<h3><b><span data-contrast=\"auto\">Uzyskaj najlepsz\u0105 mo\u017cliw\u0105 kondycj\u0119 nasienia<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Po uzyskaniu diagnozy (analiza parametr\u00f3w nasienia i DNA) mo\u017cna odzyska\u0107 kontrol\u0119. Nawet je\u015bli masz wysoki poziom fragmentacji DNA plemnik\u00f3w, mo\u017cliwe jest zmniejszenie uszkodze\u0144 DNA plemnik\u00f3w za pomoc\u0105\u00a0<\/span><span data-contrast=\"auto\">zmiany stylu \u017cycia<\/span><span data-contrast=\"auto\">i zwi\u0119kszy\u0107 prawdopodobie\u0144stwo zaj\u015bcia w ci\u0105\u017c\u0119 zar\u00f3wno w spos\u00f3b naturalny, jak i za pomoc\u0105 leczenia niep\u0142odno\u015bci, takiego jak IVF lub ICSI. \u0141atwe sposoby na popraw\u0119 zdrowia plemnik\u00f3w mo\u017cna znale\u017a\u0107 na naszej stronie\u00a0<\/span><a href=\"https:\/\/www.exseedhealth.com\/pl\/top-10-healthy-habits-to-boost-sperm\/\"><b><span data-contrast=\"none\">artyku\u0142 na blogu lifestylowym.<\/span><\/b><\/a><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3><b><span data-contrast=\"auto\">Nie zwlekaj z analiz\u0105 poziom\u00f3w uszkodze\u0144 DNA plemnik\u00f3w\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Oparte na autorskim rozwi\u0105zaniu Examen\u00a0<\/span><b><span data-contrast=\"auto\">Technologia SpermComet<\/span><\/b><span data-contrast=\"auto\">Gama test\u00f3w diagnostycznych DNA plemnik\u00f3w Exact\u00ae dostarcza niezb\u0119dnych informacji specjalistom ds. p\u0142odno\u015bci, pomagaj\u0105c im w diagnozowaniu niep\u0142odno\u015bci m\u0119skiej i podejmowaniu najlepszych decyzji dotycz\u0105cych leczenia ich pacjent\u00f3w.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Porozmawiaj z ekspertem Examen ds. p\u0142odno\u015bci na temat\u00a0<\/span><a href=\"https:\/\/examenlab.com\/for-men\/the-test\/\"><span data-contrast=\"none\">Dok\u0142adny test DNA plemnik\u00f3w<\/span><\/a><span data-contrast=\"auto\">i wyznaczy\u0107 \u015bcie\u017ck\u0119, kt\u00f3ra jest najbardziej odpowiednia dla danej osoby.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Zesp\u00f3\u0142 Examen w Wielkiej Brytanii z przyjemno\u015bci\u0105 wprowadza testy Exact do Danii, dzi\u0119ki profesorowi Peterowi Humaidanowi.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Guest blog from Prof. Sheena Lewis from Examenlab.com You may be surprised \u2013 or possibly reassured \u2013 to learn that more than a quarter of couples having fertility investigations are told that neither of them has any detectable problems (1). This is frustrating for both the fertility expert and the couples trying desperately to have [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":125903,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[198,199],"tags":[],"class_list":["post-82138","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mens-fertility","category-sperm-testing-treatment"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sperm DNA damage provides powerful insights to male fertility<\/title>\n<meta name=\"description\" content=\"Here&#039;s why you should test your sperm DNA and where you can get tested. 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