{"id":117593,"date":"2023-09-07T10:49:09","date_gmt":"2023-09-07T09:49:09","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=117593"},"modified":"2024-04-03T16:19:34","modified_gmt":"2024-04-03T15:19:34","slug":"first-model-human-embryo-without-egg-or-sperm","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/pl\/first-model-human-embryo-without-egg-or-sperm\/","title":{"rendered":"Naukowcy opracowali model ludzkiego embrionu bez kom\u00f3rki jajowej i plemnik\u00f3w"},"content":{"rendered":"

W prze\u0142omowym osi\u0105gni\u0119ciu, naukowcy z instytutu Instytut Weizmanna<\/a> z powodzeniem wyhodowali istot\u0119, kt\u00f3ra \u015bci\u015ble na\u015bladuje wczesny ludzki embrion, a wszystko to bez u\u017cycia plemnik\u00f3w, kom\u00f3rek jajowych czy macicy. Ten \"model zarodka\" stworzony przy u\u017cyciu kom\u00f3rek macierzystych wykazuje uderzaj\u0105ce podobie\u0144stwo do prawdziwego 14-dniowego ludzkiego zarodka, a nawet uwalnia hormony zdolne do wywo\u0142ania pozytywnego testu ci\u0105\u017cowego w warunkach laboratoryjnych.<\/p>\n

Dlaczego modele embrionalne maj\u0105 znaczenie<\/h2>\n

Zrozumienie pierwszych kilku tygodni po zap\u0142odnieniu, od zbioru niezr\u00f3\u017cnicowanych kom\u00f3rek do rozwoju rozpoznawalnych struktur, ma kluczowe znaczenie. Okres ten charakteryzuje si\u0119 szybkimi zmianami i jest znacz\u0105cym \u017ar\u00f3d\u0142em poronie\u0144 i wad wrodzonych, ale pozostaje s\u0142abo poznany.<\/p>\n

Badania nad embrionami od dawna stanowi\u0105 z\u0142o\u017con\u0105 i etycznie wra\u017cliw\u0105 dziedzin\u0119. Jednak naukowcy badaj\u0105 obecnie innowacyjne podej\u015bcia do replikacji naturalnego rozwoju zarodka. Ostatnie badanie, opublikowane w czasopi\u015bmie Natura<\/a>stanowi znacz\u0105cy kamie\u0144 milowy - stworzenie \"kompletnego\" modelu zarodka, kt\u00f3ry wiernie odtwarza kluczowe struktury wczesnego zarodka.<\/p>\n

Jak tego dokonali?<\/h2>\n

Zamiast u\u017cywa\u0107 tradycyjnych plemnik\u00f3w i kom\u00f3rek jajowych, naukowcy wykorzystali naiwne kom\u00f3rki macierzyste, kt\u00f3re zosta\u0142y przeprogramowane tak, aby posiada\u0142y potencja\u0142 do r\u00f3\u017cnicowania si\u0119 w dowolny rodzaj tkanki w ludzkim ciele. Te kom\u00f3rki macierzyste zosta\u0142y nast\u0119pnie nak\u0142onione do przekszta\u0142cenia si\u0119 w cztery okre\u015blone typy kom\u00f3rek wyst\u0119puj\u0105ce we wczesnych ludzkich zarodkach:<\/p>\n

    \n
  1. Kom\u00f3rki epiblastu, kt\u00f3re ostatecznie tworz\u0105 zarodek lub p\u0142\u00f3d.<\/li>\n
  2. Kom\u00f3rki trofoblastu, odpowiedzialne za rozw\u00f3j \u0142o\u017cyska.<\/li>\n
  3. Kom\u00f3rki hipoblastyczne, kt\u00f3re wsp\u00f3\u0142tworz\u0105 woreczek \u017c\u00f3\u0142tkowy.<\/li>\n
  4. Kom\u00f3rki mezodermy pozazarodkowej.<\/li>\n<\/ol>\n

    Te r\u00f3\u017cne typy kom\u00f3rek, w sumie 120 kom\u00f3rek, zosta\u0142y po\u0142\u0105czone w precyzyjnych proporcjach, a naukowcy zaobserwowali niezwyk\u0142e zjawisko, gdy oko\u0142o 1% tych kom\u00f3rek spontanicznie po\u0142\u0105czy\u0142o si\u0119 w struktur\u0119 przypominaj\u0105c\u0105 ludzki zarodek.<\/p>\n

    Obiecuj\u0105ca przysz\u0142o\u015b\u0107<\/h2>\n

    Chocia\u017c osi\u0105gni\u0119cie to jest prze\u0142omowe, rodzi ono wa\u017cne pytania etyczne, zw\u0142aszcza \u017ce te modele zarodk\u00f3w zbli\u017caj\u0105 si\u0119 do etap\u00f3w rozwojowych prawdziwych zarodk\u00f3w. Mamy nadziej\u0119, \u017ce modele te pomog\u0105 naukowcom uzyska\u0107 wgl\u0105d w to, jak powstaj\u0105 r\u00f3\u017cne typy kom\u00f3rek, pocz\u0105tkowe etapy rozwoju narz\u0105d\u00f3w oraz zrozumienie chor\u00f3b dziedzicznych lub genetycznych.<\/p>\n

    Co wi\u0119cej, istnieje mo\u017cliwo\u015b\u0107 poprawy wska\u017anik\u00f3w powodzenia zap\u0142odnienia in vitro (IVF) poprzez zbadanie, dlaczego niekt\u00f3re zarodki nie rozwijaj\u0105 si\u0119 lub poprzez wykorzystanie modeli do testowania bezpiecze\u0144stwa lek\u00f3w w czasie ci\u0105\u017cy.<\/p>\n

    Droga przed nami<\/h2>\n

    Chocia\u017c badanie to jest znacz\u0105cym krokiem naprz\u00f3d, konieczne jest zaj\u0119cie si\u0119 obecnym wska\u017anikiem niepowodze\u0144 99% w monta\u017cu tych modeli zarodk\u00f3w. Osi\u0105gni\u0119cie bardziej sp\u00f3jnych wynik\u00f3w b\u0119dzie mia\u0142o kluczowe znaczenie dla pe\u0142nego zrozumienia poronie\u0144 i niep\u0142odno\u015bci.<\/p>\n

    Co wi\u0119cej, w miar\u0119 jak modele te staj\u0105 si\u0119 coraz bardziej podobne do rzeczywistych embrion\u00f3w, pojawiaj\u0105 si\u0119 z\u0142o\u017cone pytania etyczne. Czy powinny by\u0107 one regulowane podobnie jak ludzkie embriony, czy te\u017c dopuszczalne jest bardziej swobodne podej\u015bcie? Jest to temat, kt\u00f3ry prawdopodobnie wywo\u0142a znaczn\u0105 debat\u0119.<\/p>\n

    Podsumowuj\u0105c, badania te stanowi\u0105 kamie\u0144 milowy w dziedzinie rozwoju zarodk\u00f3w. Oferuje obiecuj\u0105c\u0105 \u015bcie\u017ck\u0119 do badania skomplikowanych wydarze\u0144, kt\u00f3re prowadz\u0105 do formowania si\u0119 planu ludzkiego cia\u0142a, rzucaj\u0105c \u015bwiat\u0142o na wcze\u015bniej enigmatyczny okres rozwoju cz\u0142owieka. W duchu post\u0119pu naukowego zach\u0119ca nas to do dalszego odkrywania granic naszego rozumienia samego \u017cycia.<\/p>\n

     <\/p>\n

    Chcesz zrozumie\u0107 i poprawi\u0107 swoj\u0105 m\u0119sk\u0105 p\u0142odno\u015b\u0107? Niewiele os\u00f3b zdaje sobie spraw\u0119, \u017ce 40% niep\u0142odno\u015bci jest spowodowanych czynnikiem m\u0119skim! Przy ExSeed<\/a> opracowali\u015bmy zestaw do domowego badania nasienia, dzi\u0119ki kt\u00f3remu mo\u017cesz zobaczy\u0107 swoje plemniki pod mikroskopem i pozna\u0107 ca\u0142kowit\u0105 liczb\u0119 ruchliwych plemnik\u00f3w, a wszystko to w zaciszu w\u0142asnego domu. Dowiedz si\u0119 wi\u0119cej o Test nasienia ExSeed<\/a> tutaj.<\/p>","protected":false},"excerpt":{"rendered":"

    In a ground-breaking achievement, scientists at the Weizmann Institute have successfully grown an entity that closely mimics an early human embryo, all without the use of sperm, eggs, or a womb. This “embryo model” created using stem cells bears a striking resemblance to a real 14-day-old human embryo and even releases hormones capable of triggering […]<\/p>\n","protected":false},"author":3,"featured_media":124590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[203,198],"tags":[],"class_list":["post-117593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-community","category-mens-fertility"],"acf":[],"yoast_head":"\nFirst Model Human Embryo Made Without Sperm or Egg<\/title>\n<meta name=\"description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/pl\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Model Human Embryo Made Without Sperm or Egg\" \/>\n<meta property=\"og:description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.exseedhealth.com\/pl\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:site_name\" content=\"ExSeed Health\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ExSeedHealth\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-07T09:49:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-03T15:19:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.exseedhealth.com\/wp-content\/uploads\/2023\/09\/sperm-volume-1920x1080-1-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Emil Andersen, PhD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:site\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:label1\" content=\"Napisane przez\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emil Andersen, PhD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Szacowany czas czytania\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuty\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\"},\"author\":{\"name\":\"Emil Andersen, PhD\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#\\\/schema\\\/person\\\/5d08eb43d90734a01dcf3cb77ce5e109\"},\"headline\":\"Scientists Develop Model Human Embryo Without Egg or Sperm\",\"datePublished\":\"2023-09-07T09:49:09+00:00\",\"dateModified\":\"2024-04-03T15:19:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\"},\"wordCount\":584,\"publisher\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.exseedhealth.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/sperm-volume-1920x1080-1-1.jpg\",\"articleSection\":[\"Community\",\"Men\u2019s Fertility\"],\"inLanguage\":\"pl-PL\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\",\"url\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/\",\"name\":\"First Model Human Embryo Made Without Sperm or Egg\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/first-model-human-embryo-without-egg-or-sperm\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.exseedhealth.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/sperm-volume-1920x1080-1-1.jpg\",\"datePublished\":\"2023-09-07T09:49:09+00:00\",\"dateModified\":\"2024-04-03T15:19:34+00:00\",\"description\":\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. 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He is renowned for being the lead author of the most extensive study to date on the impact of weight loss on semen quality. During his tenure at the University of Cambridge, Emil spearheaded innovative research focused on deciphering the fundamental mechanisms of sperm and developing methods to assess their fertility potential. His contributions to the field are widely recognized, with multiple publications in esteemed peer-reviewed scientific journals.\",\"url\":\"https:\\\/\\\/www.exseedhealth.com\\\/pl\\\/author\\\/ea\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Pierwszy model ludzkiego embrionu wykonany bez plemnik\u00f3w i kom\u00f3rki jajowej","description":"Te w pe\u0142ni rozwini\u0119te syntetyczne modele, odpowiadaj\u0105ce 14-dniowemu zarodkowi, mog\u0105 utorowa\u0107 drog\u0119 do nowych bada\u0144 nad niep\u0142odno\u015bci\u0105. 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