{"id":150021,"date":"2025-07-31T15:42:03","date_gmt":"2025-07-31T14:42:03","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=150021"},"modified":"2025-11-12T14:08:30","modified_gmt":"2025-11-12T14:08:30","slug":"autoimmune-diseases-in-men-how-they-impact-male-fertility","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/it\/autoimmune-diseases-in-men-how-they-impact-male-fertility\/","title":{"rendered":"Malattie autoimmuni negli uomini: come influiscono sulla fertilit\u00e0 maschile"},"content":{"rendered":"<p>Le malattie autoimmuni colpiscono milioni di persone in tutto il mondo e alcune di esse si manifestano pi\u00f9 spesso o pi\u00f9 gravemente negli uomini. Queste condizioni causano generalmente infiammazioni e problemi agli organi, ma hanno anche effetti sulla fertilit\u00e0, un effetto collaterale spesso trascurato. Di seguito, esploriamo cinque malattie autoimmuni pi\u00f9 comuni negli uomini e spieghiamo come ognuna di esse pu\u00f2 danneggiare la salute riproduttiva.<\/p>\n<h2>Spondilite anchilosante (AS)<\/h2>\n<p><strong>Che cos'\u00e8:<\/strong><br \/>\nLa spondilite anchilosante \u00e8 un tipo di artrite infiammatoria che colpisce principalmente la colonna vertebrale e le articolazioni della schiena. Spesso inizia nella prima et\u00e0 adulta e si manifesta con una frequenza da due a tre volte maggiore negli uomini (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Braun%20J%2C%20Sieper%20J.%20Ankylosing%20spondylitis.%20Lancet.%202007%20Apr%2021%3B369%289570%29%3A1379%E2%80%9390.\" target=\"_blank\" rel=\"noopener noreferrer\">Braun &amp; Sieper, 2007<\/a>).<\/p>\n<p><strong>Impatto sulla fertilit\u00e0:<\/strong><\/p>\n<ul>\n<li>L'infiammazione cronica aumenta lo stress ossidativo, che pu\u00f2 danneggiare la forma, il movimento e il DNA degli spermatozoi (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ricci%20G%2C%20et%20al.%20Semen%20quality%20in%20young%20men%20with%20ankylosing%20spondylitis%20treated%20with%20NSAIDs%20or%20TNF-%CE%B1%20inhibitors.%20Fertil%20Steril.%202009.\" target=\"_blank\" rel=\"noopener noreferrer\">Ricci et al., 2009<\/a>).<\/li>\n<li>Gli ormoni infiammatori possono abbassare il testosterone e rallentare la produzione di sperma.<\/li>\n<li>Il dolore, la rigidit\u00e0 e l'affaticamento spesso provocano problemi di erezione e calo della libido.<\/li>\n<li>I farmaci chiamati inibitori del TNF (come etanercept o adalimumab) sembrano sicuri per la fertilit\u00e0 e possono persino migliorare la salute dello sperma (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mahmoud%20AM%2C%20et%20al.%20Effects%20of%20etanercept%20on%20male%20fertility%20in%20patients%20with%20AS.%20Rheumatol%20Int.%202011.\" target=\"_blank\" rel=\"noopener noreferrer\">Mahmoud et al., 2011<\/a>).<\/li>\n<\/ul>\n<h2>Psoriasi e artrite psoriasica (PsA)<\/h2>\n<p><strong>Che cos'\u00e8:<\/strong><br \/>\nLa psoriasi \u00e8 una patologia cutanea di lunga durata che provoca chiazze rosse e squamose. Circa 30% delle persone affette da psoriasi sviluppano anche l'artrite psoriasica, che causa dolore e gonfiore alle articolazioni. Queste condizioni tendono a comparire prima e a progredire pi\u00f9 rapidamente negli uomini.<\/p>\n<p><strong>Impatto sulla fertilit\u00e0:<\/strong><\/p>\n<ul>\n<li>L'infiammazione aumenta lo stress ossidativo nello sperma, che pu\u00f2 ridurre il numero e il movimento degli spermatozoi.<\/li>\n<li>I sintomi cutanei visibili e il dolore possono influire sulla fiducia in se stessi e portare a evitare i rapporti sessuali.<\/li>\n<li>Sostanze chimiche infiammatorie come il TNF-alfa e l'IL-17 possono alterare l'equilibrio ormonale e ridurre il testosterone.<\/li>\n<li>I trattamenti che bloccano queste citochine, come gli inibitori del TNF o dell'IL-17, sono generalmente sicuri per gli uomini che desiderano avere figli (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Micu%20MC%2C%20et%20al.%20Effects%20of%20IL-17%20and%20TNF%20inhibitors%20on%20male%20reproductive%20function.%20Reprod%20Biol%20Endocrinol.%202023.\" target=\"_blank\" rel=\"noopener noreferrer\">Micu et al., 2023<\/a>).<\/li>\n<\/ul>\n<h2>Artrite reumatoide (RA)<\/h2>\n<p><strong>Che cos'\u00e8:<\/strong><br \/>\nL'artrite reumatoide \u00e8 una malattia autoimmune che attacca principalmente le articolazioni, ma pu\u00f2 colpire anche tutto il corpo. Sebbene sia pi\u00f9 comune nelle donne, gli uomini spesso sperimentano una forma pi\u00f9 aggressiva della malattia.<\/p>\n<p><strong>Impatto sulla fertilit\u00e0:<\/strong><\/p>\n<ul>\n<li>Gli uomini affetti da RA hanno spesso livelli pi\u00f9 bassi di testosterone e pi\u00f9 alti di LH, segno di uno squilibrio ormonale (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kiss%20E%2C%20et%20al.%20Hormonal%20disturbances%20in%20men%20with%20rheumatoid%20arthritis.%20Clin%20Rheumatol.%202005.\" target=\"_blank\" rel=\"noopener noreferrer\">Kiss et al., 2005<\/a>).<\/li>\n<li>Un'infiammazione continua pu\u00f2 danneggiare il DNA dello sperma e ridurne la qualit\u00e0.<\/li>\n<li>Depressione, affaticamento e dolori articolari possono ridurre la libido e influire sulle prestazioni sessuali.<\/li>\n<li>I comuni farmaci per l'AR, tra cui il metotrexato e i biologici, di solito non danneggiano la fertilit\u00e0, ma i medici talvolta consigliano di fare una breve pausa prima di provare a concepire.<\/li>\n<\/ul>\n<h2>Diabete mellito di tipo 1 (T1DM)<\/h2>\n<p><strong>Che cos'\u00e8:<\/strong><br \/>\nIl diabete di tipo 1 \u00e8 una condizione autoimmune che distrugge le cellule del pancreas che producono insulina. Di solito inizia nell'infanzia o nell'adolescenza e richiede un trattamento insulinico quotidiano.<\/p>\n<p><strong>Impatto sulla fertilit\u00e0:<\/strong><\/p>\n<ul>\n<li>La glicemia elevata aumenta lo stress ossidativo e danneggia i piccoli vasi sanguigni, il che pu\u00f2 danneggiare il DNA degli spermatozoi e ridurne la motilit\u00e0 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Agbaje%20IM%2C%20et%20al.%20Increased%20sperm%20DNA%20damage%20in%20diabetic%20men.%20Reprod%20Biomed%20Online.%202007.\" target=\"_blank\" rel=\"noopener noreferrer\">Agbaje et al., 2007<\/a>).<\/li>\n<li>I danni ai nervi possono causare disfunzione erettile o eiaculazione retrograda.<\/li>\n<li>Un cattivo controllo del glucosio pu\u00f2 alterare gli ormoni e abbassare il testosterone.<\/li>\n<li>Il trattamento insulinico di per s\u00e9 non danneggia la fertilit\u00e0, ma mantenere costante la glicemia protegge la salute riproduttiva.<\/li>\n<\/ul>\n<h2>Colangite sclerosante primaria (PSC)<\/h2>\n<p><strong>Che cos'\u00e8:<\/strong><br \/>\nLa PSC \u00e8 una malattia cronica del fegato che causa infiammazione e cicatrizzazione dei dotti biliari. Colpisce pi\u00f9 spesso gli uomini che le donne e spesso si manifesta insieme alla colite ulcerosa, una malattia infiammatoria intestinale.<\/p>\n<p><strong>Impatto sulla fertilit\u00e0:<\/strong><\/p>\n<ul>\n<li>I problemi epatici possono interferire con l'equilibrio ormonale, riducendo il testosterone e il desiderio sessuale.<\/li>\n<li>La stanchezza costante pu\u00f2 causare difficolt\u00e0 sessuali e ridurre la motivazione.<\/li>\n<li>Sebbene i dati siano limitati, \u00e8 probabile che l'infiammazione contribuisca al danno ossidativo dello sperma.<\/li>\n<li>Farmaci come l'acido ursodesossicolico (UDCA) e i bloccanti del TNF usati per l'IBD sembrano generalmente sicuri per la fertilit\u00e0 maschile.<\/li>\n<\/ul>\n<h2>Conclusione<\/h2>\n<p>Le malattie autoimmuni comportano molte sfide per gli uomini: non solo dolore e affaticamento, ma anche potenziali effetti sulla fertilit\u00e0. L'infiammazione, lo stress ossidativo e gli sbalzi ormonali possono danneggiare lo sperma e compromettere la salute sessuale. Tuttavia, c'\u00e8 una buona notizia: la maggior parte dei trattamenti moderni, soprattutto i farmaci biologici, sembrano sicuri per la funzione riproduttiva maschile.<\/p>\n<p><strong>Gli uomini affetti da patologie autoimmuni possono utilizzare <a href=\"https:\/\/shop.exseedhealth.com\/collections\/male-fertility-test-kits\" target=\"_blank\" rel=\"noopener noreferrer\">kit per l'analisi dello sperma a casa<\/a> per monitorare la salute della fertilit\u00e0<\/strong> - tra cui il numero, la forma e la motilit\u00e0 degli spermatozoi. I test prima o durante il trattamento aiutano gli uomini a prendere decisioni sicure e a collaborare pi\u00f9 strettamente con i loro medici.<\/p>\n<p>Gestendo precocemente l'attivit\u00e0 della malattia e monitorando regolarmente la fertilit\u00e0, gli uomini possono proteggere la loro salute riproduttiva e pianificare con fiducia la futura genitorialit\u00e0.<\/p>","protected":false},"excerpt":{"rendered":"<p>Autoimmune diseases affect millions of people around the world, and some of them appear more often or more severely in men. These conditions usually cause inflammation and organ problems, but they also affect fertility \u2014 a side effect that\u2019s often overlooked. Below, we explore five autoimmune diseases that are more common in men and explain [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":150025,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[200,198],"tags":[],"class_list":["post-150021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle-environmental","category-mens-fertility"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How Autoimmune Diseases Affect Male Fertility<\/title>\n<meta name=\"description\" content=\"Discover how autoimmune diseases impact male fertility, plus how at-home sperm testing can help men monitor reproductive health.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/it\/autoimmune-diseases-in-men-how-they-impact-male-fertility\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Autoimmune Diseases Affect Male Fertility\" \/>\n<meta property=\"og:description\" content=\"Discover how autoimmune diseases impact male fertility, plus how at-home sperm testing can help men monitor reproductive health.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.exseedhealth.com\/it\/autoimmune-diseases-in-men-how-they-impact-male-fertility\/\" \/>\n<meta property=\"og:site_name\" content=\"ExSeed Health\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ExSeedHealth\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-31T14:42:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-12T14:08:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.exseedhealth.com\/wp-content\/uploads\/2025\/07\/Visualizing-the-Impact-of-Autoimmune-Disease-1024x576.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"576\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Emil Andersen, PhD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:site\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emil Andersen, PhD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/autoimmune-diseases-in-men-how-they-impact-male-fertility\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/autoimmune-diseases-in-men-how-they-impact-male-fertility\\\/\"},\"author\":{\"name\":\"Emil Andersen, PhD\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#\\\/schema\\\/person\\\/5d08eb43d90734a01dcf3cb77ce5e109\"},\"headline\":\"Autoimmune Diseases in Men: How They Impact Male Fertility\",\"datePublished\":\"2025-07-31T14:42:03+00:00\",\"dateModified\":\"2025-11-12T14:08:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/autoimmune-diseases-in-men-how-they-impact-male-fertility\\\/\"},\"wordCount\":690,\"publisher\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/autoimmune-diseases-in-men-how-they-impact-male-fertility\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.exseedhealth.com\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Visualizing-the-Impact-of-Autoimmune-Disease.png\",\"articleSection\":[\"Lifestyle &amp; 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