{"id":117593,"date":"2023-09-07T10:49:09","date_gmt":"2023-09-07T09:49:09","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=117593"},"modified":"2024-04-03T16:19:34","modified_gmt":"2024-04-03T15:19:34","slug":"first-model-human-embryo-without-egg-or-sperm","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/it\/first-model-human-embryo-without-egg-or-sperm\/","title":{"rendered":"Gli scienziati sviluppano un modello di embrione umano senza ovulo o spermatozoo"},"content":{"rendered":"<p>In un risultato rivoluzionario, gli scienziati del <a href=\"https:\/\/wis-wander.weizmann.ac.il\/life-sciences\/human-embryo-models-grown-stem-cells\">Istituto Weizmann<\/a> hanno coltivato con successo un'entit\u00e0 che imita da vicino un embrione umano precoce, il tutto senza l'uso di sperma, ovuli o utero. Questo \"modello di embrione\" creato con cellule staminali assomiglia molto a un vero embrione umano di 14 giorni e rilascia persino ormoni in grado di innescare un test di gravidanza positivo in laboratorio.<\/p>\n<h2>Perch\u00e9 i modelli embrionali sono importanti<\/h2>\n<p>La comprensione delle prime settimane dopo la fecondazione, da un insieme di cellule indifferenziate allo sviluppo di strutture riconoscibili, \u00e8 fondamentale. Questo periodo \u00e8 caratterizzato da rapidi cambiamenti ed \u00e8 una fonte significativa di aborti spontanei e difetti alla nascita, eppure rimane poco conosciuto.<\/p>\n<p>La ricerca sugli embrioni \u00e8 stata a lungo un campo complesso ed eticamente sensibile. Tuttavia, i ricercatori stanno ora esplorando approcci innovativi per replicare lo sviluppo naturale degli embrioni. Questo recente studio, pubblicato sulla rivista <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06604-5\">Natura<\/a>rappresenta un'importante pietra miliare: la creazione di un modello embrionale \"completo\" che riproduce fedelmente le strutture embrionali precoci.<\/p>\n<h2>Come hanno fatto?<\/h2>\n<p>Invece di utilizzare spermatozoi e ovuli tradizionali, gli scienziati hanno utilizzato cellule staminali ingenue che sono state riprogrammate per avere il potenziale di differenziarsi in qualsiasi tipo di tessuto all'interno del corpo umano. Queste cellule staminali sono state poi indotte a svilupparsi in quattro tipi di cellule specifiche presenti nei primi embrioni umani:<\/p>\n<ol>\n<li>Cellule dell'epiblasto, che alla fine formano l'embrione o il feto.<\/li>\n<li>Cellule del trofoblasto, responsabili dello sviluppo della placenta.<\/li>\n<li>Cellule ipoblaste, che contribuiscono al sacco vitellino.<\/li>\n<li>Cellule del mesoderma extraembrionale.<\/li>\n<\/ol>\n<p>Questi diversi tipi di cellule, per un totale di 120, sono stati combinati in rapporti precisi e i ricercatori hanno osservato un fenomeno straordinario: circa 1% di queste cellule si sono auto-assemblate spontaneamente in una struttura che assomiglia a un embrione umano.<\/p>\n<h2>Un futuro promettente<\/h2>\n<p>Se da un lato questo risultato \u00e8 innovativo, dall'altro solleva importanti questioni etiche, soprattutto perch\u00e9 questi modelli embrionali si avvicinano molto alle fasi di sviluppo degli embrioni reali. La speranza \u00e8 che questi modelli aiutino gli scienziati a capire come emergono i vari tipi di cellule, le fasi iniziali dello sviluppo degli organi e la comprensione delle malattie ereditarie o genetiche.<\/p>\n<p>Inoltre, \u00e8 possibile migliorare le percentuali di successo della fecondazione in vitro (FIV) studiando il motivo per cui alcuni embrioni non si sviluppano o utilizzando i modelli per testare la sicurezza dei farmaci durante la gravidanza.<\/p>\n<h2>La strada da percorrere<\/h2>\n<p>Sebbene questo studio rappresenti un significativo passo avanti, \u00e8 essenziale affrontare l'attuale tasso di fallimento della 99% nell'assemblaggio di questi modelli di embrioni. Ottenere risultati pi\u00f9 coerenti sar\u00e0 fondamentale per comprendere appieno gli aborti spontanei e l'infertilit\u00e0.<\/p>\n<p>Inoltre, man mano che questi modelli si avvicinano a somigliare agli embrioni reali, sollevano complesse questioni etiche. Devono essere regolamentati in modo simile agli embrioni umani o \u00e8 accettabile un approccio pi\u00f9 rilassato? \u00c8 un argomento che probabilmente susciter\u00e0 un notevole dibattito.<\/p>\n<p>In sintesi, questa ricerca rappresenta una notevole pietra miliare nel campo dello sviluppo embrionale. Offre un percorso promettente per studiare gli intricati eventi che portano alla formazione della pianta del corpo umano, facendo luce su un periodo precedentemente enigmatico dello sviluppo umano. E nello spirito del progresso scientifico, ci incoraggia a continuare a esplorare i confini della nostra comprensione della vita stessa.<\/p>\n<p>&nbsp;<\/p>\n<p>Volete capire e migliorare la vostra fertilit\u00e0 maschile? Pochi sanno che 40% delle infertilit\u00e0 sono dovute al fattore maschile! A <a href=\"https:\/\/www.exseedhealth.com\/it\/\">Negozio<\/a> abbiamo sviluppato un kit per il test dello sperma completamente a domicilio, che vi permette di vedere le vostre cellule spermatiche al microscopio e di conoscere la vostra conta totale degli spermatozoi mobili, il tutto nella comodit\u00e0 di casa vostra. Per saperne di pi\u00f9 sul <a href=\"https:\/\/www.exseedhealth.com\/it\/exseed-home-sperm-test\/\">Test dello sperma ExSeed<\/a> qui.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a ground-breaking achievement, scientists at the Weizmann Institute have successfully grown an entity that closely mimics an early human embryo, all without the use of sperm, eggs, or a womb. This &#8220;embryo model&#8221; created using stem cells bears a striking resemblance to a real 14-day-old human embryo and even releases hormones capable of triggering [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":124590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[203,198],"tags":[],"class_list":["post-117593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-community","category-mens-fertility"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>First Model Human Embryo Made Without Sperm or Egg<\/title>\n<meta name=\"description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/it\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Model Human Embryo Made Without Sperm or Egg\" \/>\n<meta property=\"og:description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. 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Durante il suo incarico all'Universit\u00e0 di Cambridge, Emil ha guidato una ricerca innovativa incentrata sulla decifrazione dei meccanismi fondamentali dello sperma e sullo sviluppo di metodi per valutarne il potenziale di fertilit\u00e0. I suoi contributi al settore sono ampiamente riconosciuti, con numerose pubblicazioni in stimate riviste scientifiche peer-reviewed.","url":"https:\/\/www.exseedhealth.com\/it\/author\/ea\/"}]}},"_links":{"self":[{"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/posts\/117593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/comments?post=117593"}],"version-history":[{"count":0,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/posts\/117593\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/media\/124590"}],"wp:attachment":[{"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/media?parent=117593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/categories?post=117593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.exseedhealth.com\/it\/wp-json\/wp\/v2\/tags?post=117593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}