{"id":117593,"date":"2023-09-07T10:49:09","date_gmt":"2023-09-07T09:49:09","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=117593"},"modified":"2024-04-03T16:19:34","modified_gmt":"2024-04-03T15:19:34","slug":"first-model-human-embryo-without-egg-or-sperm","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/es\/first-model-human-embryo-without-egg-or-sperm\/","title":{"rendered":"Cient\u00edficos desarrollan un embri\u00f3n humano modelo sin \u00f3vulo ni esperma"},"content":{"rendered":"<p>En un logro pionero, cient\u00edficos de la <a href=\"https:\/\/wis-wander.weizmann.ac.il\/life-sciences\/human-embryo-models-grown-stem-cells\">Instituto Weizmann<\/a> han logrado cultivar una entidad que imita fielmente a un embri\u00f3n humano temprano, todo ello sin utilizar esperma, \u00f3vulos ni \u00fatero. Este \"modelo de embri\u00f3n\" creado mediante c\u00e9lulas madre tiene un parecido asombroso con un embri\u00f3n humano real de 14 d\u00edas e incluso libera hormonas capaces de desencadenar una prueba de embarazo positiva en un entorno de laboratorio.<\/p>\n<h2>Por qu\u00e9 son importantes los modelos de embriones<\/h2>\n<p>Comprender las primeras semanas tras la fecundaci\u00f3n, desde un conjunto de c\u00e9lulas indiferenciadas hasta el desarrollo de estructuras reconocibles, es crucial. Este periodo est\u00e1 marcado por cambios r\u00e1pidos y es una fuente importante de abortos espont\u00e1neos y defectos cong\u00e9nitos, pero sigue siendo poco conocido.<\/p>\n<p>La investigaci\u00f3n con embriones ha sido durante mucho tiempo un campo complejo y \u00e9ticamente delicado. Sin embargo, los investigadores exploran ahora enfoques innovadores para reproducir el desarrollo embrionario natural. Este estudio reciente, publicado en la revista <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06604-5\">Naturaleza<\/a>representa un hito importante: la creaci\u00f3n de un modelo embrionario \"completo\" que reproduce fielmente estructuras embrionarias tempranas clave.<\/p>\n<h2>\u00bfC\u00f3mo lo hicieron?<\/h2>\n<p>En lugar de utilizar el esperma y el \u00f3vulo tradicionales, los cient\u00edficos utilizaron c\u00e9lulas madre ingenuas reprogramadas para poseer el potencial de diferenciarse en cualquier tipo de tejido del cuerpo humano. A continuaci\u00f3n, se persuadi\u00f3 a estas c\u00e9lulas madre para que se desarrollaran en cuatro tipos celulares espec\u00edficos que se encuentran en los embriones humanos tempranos:<\/p>\n<ol>\n<li>C\u00e9lulas del epiblasto, que acaban formando el embri\u00f3n o feto.<\/li>\n<li>C\u00e9lulas trofobl\u00e1sticas, responsables del desarrollo de la placenta.<\/li>\n<li>C\u00e9lulas del hipoblasto, que contribuyen al saco vitelino.<\/li>\n<li>C\u00e9lulas del mesodermo extraembrionario.<\/li>\n<\/ol>\n<p>Estos diversos tipos de c\u00e9lulas, un total de 120, se combinaron en proporciones precisas, y los investigadores observaron el notable fen\u00f3meno de que aproximadamente 1% de estas c\u00e9lulas se autoensamblaron espont\u00e1neamente en una estructura parecida a un embri\u00f3n humano.<\/p>\n<h2>Un futuro prometedor<\/h2>\n<p>Aunque este logro es pionero, plantea importantes cuestiones \u00e9ticas, sobre todo porque estos modelos embrionarios se aproximan mucho a las fases de desarrollo de los embriones reales. La esperanza es que estos modelos ayuden a los cient\u00edficos a comprender mejor c\u00f3mo surgen los distintos tipos de c\u00e9lulas, las fases iniciales del desarrollo de los \u00f3rganos y la comprensi\u00f3n de las enfermedades hereditarias o gen\u00e9ticas.<\/p>\n<p>Adem\u00e1s, existe la posibilidad de mejorar las tasas de \u00e9xito de la fecundaci\u00f3n in vitro (FIV) investigando por qu\u00e9 algunos embriones no se desarrollan o utilizando los modelos para probar la seguridad de los medicamentos durante el embarazo.<\/p>\n<h2>El camino por recorrer<\/h2>\n<p>Aunque este estudio supone un importante avance, es esencial abordar la actual tasa de fallos del 99% en el ensamblaje de estos modelos de embriones. Conseguir resultados m\u00e1s consistentes ser\u00e1 vital para comprender plenamente los abortos espont\u00e1neos y la infertilidad.<\/p>\n<p>Adem\u00e1s, a medida que estos modelos se asemejan m\u00e1s a los embriones reales, plantean cuestiones \u00e9ticas complejas. \u00bfDeben regularse de forma similar a los embriones humanos, o es aceptable un enfoque m\u00e1s relajado? Es un tema que probablemente suscitar\u00e1 un debate considerable.<\/p>\n<p>En resumen, esta investigaci\u00f3n representa un hito notable en el campo del desarrollo embrionario. Ofrece una v\u00eda prometedora para estudiar los intrincados acontecimientos que conducen a la formaci\u00f3n del plan corporal humano, arrojando luz sobre un periodo hasta ahora enigm\u00e1tico del desarrollo humano. Y en el esp\u00edritu del progreso cient\u00edfico, nos anima a seguir explorando los l\u00edmites de nuestra comprensi\u00f3n de la vida misma.<\/p>\n<p>&nbsp;<\/p>\n<p>\u00bfQuieres comprender y mejorar tu fertilidad masculina? \u00a1Poca gente sabe que el 40% de las infertilidades se deben al factor masculino! En <a href=\"https:\/\/www.exseedhealth.com\/es\/\">Tienda<\/a> hemos desarrollado un kit de an\u00e1lisis de esperma totalmente casero, que te permite ver tus espermatozoides al microscopio y conocer tu recuento total de espermatozoides m\u00f3viles, todo ello en la comodidad de tu propia casa. M\u00e1s informaci\u00f3n <a href=\"https:\/\/www.exseedhealth.com\/es\/exseed-home-sperm-test\/\">Prueba de esperma ExSeed<\/a> aqu\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a ground-breaking achievement, scientists at the Weizmann Institute have successfully grown an entity that closely mimics an early human embryo, all without the use of sperm, eggs, or a womb. This &#8220;embryo model&#8221; created using stem cells bears a striking resemblance to a real 14-day-old human embryo and even releases hormones capable of triggering [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":124590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[203,198],"tags":[],"class_list":["post-117593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-community","category-mens-fertility"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>First Model Human Embryo Made Without Sperm or Egg<\/title>\n<meta name=\"description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. Read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/es\/first-model-human-embryo-without-egg-or-sperm\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Model Human Embryo Made Without Sperm or Egg\" \/>\n<meta property=\"og:description\" content=\"These fully developed synthetic models, equivalent to a day 14 embryo, could pave the way for fresh explorations in infertility. 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Es conocido por ser el autor principal del estudio m\u00e1s amplio realizado hasta la fecha sobre el impacto de la p\u00e9rdida de peso en la calidad del semen. Durante su estancia en la Universidad de Cambridge, Emil encabez\u00f3 una investigaci\u00f3n innovadora centrada en descifrar los mecanismos fundamentales del esperma y desarrollar m\u00e9todos para evaluar su potencial de fertilidad. Sus contribuciones a este campo son ampliamente reconocidas, con m\u00faltiples publicaciones en prestigiosas revistas cient\u00edficas revisadas por expertos.","url":"https:\/\/www.exseedhealth.com\/es\/author\/ea\/"}]}},"_links":{"self":[{"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/posts\/117593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/comments?post=117593"}],"version-history":[{"count":0,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/posts\/117593\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/media\/124590"}],"wp:attachment":[{"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/media?parent=117593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/categories?post=117593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.exseedhealth.com\/es\/wp-json\/wp\/v2\/tags?post=117593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}