{"id":120937,"date":"2023-10-21T10:55:36","date_gmt":"2023-10-21T09:55:36","guid":{"rendered":"https:\/\/www.exseedhealth.com\/?p=120937"},"modified":"2024-03-20T16:06:31","modified_gmt":"2024-03-20T16:06:31","slug":"mens-biological-clock","status":"publish","type":"post","link":"https:\/\/www.exseedhealth.com\/da\/mens-biological-clock\/","title":{"rendered":"Har m\u00e6nd et biologisk ur? Mandlig fertilitet og alder"},"content":{"rendered":"

N\u00e5r vi t\u00e6nker p\u00e5 alderens indvirkning p\u00e5 fertiliteten, t\u00e6nker vi ofte p\u00e5 kvinder og fokuserer p\u00e5 den faldende \u00e6gproduktion, kromosomproblemer og infertilitet. En unders\u00f8gelse viste endda, at 1 ud af 5 m\u00e6nd mener, at infertilitet kun er et kvindeproblem. Men her er noget, der ikke bliver talt om s\u00e5 ofte - alderens indvirkning p\u00e5 mandlig fertilitet. Bliver m\u00e6nd nogensinde r\u00e5det til at v\u00e6re mere opm\u00e6rksomme p\u00e5 deres biologiske ur?<\/p>\n

 <\/p>\n

Aldersfaktoren: Udskydelse af faderskab<\/h2>\n

Overraskende nok er der i mange lande ingen, der frar\u00e5der \u00e6ldre m\u00e6nd at blive f\u00e6dre, i mods\u00e6tning til den m\u00e5de, hvorp\u00e5 \u00e6ldre kvinder ofte frar\u00e5des at blive m\u00f8dre. National Institute for Clinical Excellence i England og Wales, for eksempel, anbefaler, at NHS ikke tilbyder IVF til kvinder over 42 \u00e5r<\/a>, men der st\u00e5r ikke noget om faderens alder i vejledningen. Sp\u00f8rgsm\u00e5let om, hvad der betragtes som \"gammelt\" i forbindelse med faderskab, forbliver stort set uadresseret.<\/p>\n

Ikke desto mindre viser forskning, at omkring 40-\u00e5rsalderen begynder m\u00e6nds s\u00e6d at blive langsommere, hvilket g\u00f8r undfangelse mere udfordrende. Desuden har b\u00f8rn f\u00f8dt af \u00e6ldre f\u00e6dre en \u00f8get risiko for tilstande som autisme, skizofreni og leuk\u00e6mi.<\/p>\n

I USA er der en stigende tendens til, at m\u00e6nd bliver f\u00e6dre i en h\u00f8jere alder. I 1980 blev omkring 43 ud af 1.000 b\u00f8rn f\u00f8dt af m\u00e6nd i alderen 35-49 \u00e5r. I 2015 var dette tal steget til omkring 69 ud af 1.000 babyer<\/a>.<\/p>\n

 <\/p>\n

Hvorfor s\u00e6dkvalitet betyder noget: Alderens indflydelse<\/h2>\n

Faderens alder p\u00e5virker ogs\u00e5 s\u00e6dkvaliteten. Et systematisk review fra 2015, som unders\u00f8gte 90 studier med 93.839 fors\u00f8gspersoner, afsl\u00f8rede, at en mands alder har en negativ indvirkning p\u00e5 s\u00e6dkvaliteten, herunder udseende, bev\u00e6gelighed og DNA-skader.<\/p>\n

S\u00e6dkvaliteten spiller en afg\u00f8rende rolle, n\u00e5r et barn skal undfanges. I en unders\u00f8gelse med 2.112 britiske par viste det sig, at m\u00e6nd over 45 var n\u00e6sten fem gange mere tilb\u00f8jelige til at v\u00e6re mere end et \u00e5r om at blive gravide sammenlignet med m\u00e6nd under 25, selv n\u00e5r den kvindelige partner var ung.<\/p>\n

 <\/p>\n

Risikoen ved at f\u00e5 b\u00f8rn senere<\/h2>\n

Resultaterne af in vitro-befrugtning (IVF) for \u00e6ldre m\u00e6nd ser ogs\u00e5 ud til at v\u00e6re mindre gunstige. Et nyligt studie, der unders\u00f8gte 11 forskningsartikler og 10.527 \u00e6gdonationscyklusser, fandt, at m\u00e6nds stigende alder var forbundet med et lille fald i antallet af levendef\u00f8dte.<\/p>\n

B\u00f8rn undfanget af \u00e6ldre m\u00e6nd har ogs\u00e5 en h\u00f8jere risiko for abort, d\u00f8df\u00f8dsel og at blive f\u00f8dt for tidligt. Det understreger misforst\u00e5elsen om, at hvis s\u00e6dceller kan sv\u00f8mme og tr\u00e6nge ind i et \u00e6g, er alt i orden - en opfattelse, som mange, herunder nogle l\u00e6ger, endnu ikke helt har forst\u00e5et.<\/p>\n

\u00c6ldre f\u00e6dre er mere tilb\u00f8jelige til at f\u00e5 b\u00f8rn med f\u00f8dselsdefekter, visse kr\u00e6ftformer og neurologiske lidelser. Forskning viser, at \u00e6ldre f\u00e6dre er mere tilb\u00f8jelige til at f\u00e5 b\u00f8rn med f\u00f8dselsdefekter som f.eks. l\u00e6bespalte, og de har en \u00f8get risiko for visse former for kr\u00e6ft i barndommen.<\/p>\n

S\u00e5 hvad ligger der bag disse alarmerende statistikker? Hvorfor ser vi flere \u00e6ldre f\u00e6dre i nyhederne, f.eks. mandlige ber\u00f8mtheder, der f\u00e5r b\u00f8rn, n\u00e5r de er i 70'erne og 80'erne? \u00c5rsagen ligger i den kontinuerlige produktion af s\u00e6dceller gennem en mands liv. S\u00e6dceller produceres ca. hver 74. dag, og m\u00e6nd l\u00f8ber ikke t\u00f8r for dem. Men forskning tyder p\u00e5, at jo l\u00e6ngere s\u00e6dproduktionen forts\u00e6tter, jo st\u00f8rre er sandsynligheden for at introducere genetiske mutationer.<\/p>\n

 <\/p>\n

Forst\u00e5else af reproduktionsprocessen<\/h2>\n

S\u00e6dproduktionen er baseret p\u00e5 spermatogoniale stamceller, som l\u00f8bende fornyer sig selv gennem celledeling. Men ved hver replikation er der en chance for kopieringsfejl. Jo \u00e6ldre en mand er, jo flere gange replikeres disse stamceller, hvilket f\u00f8rer til flere muligheder for fejl. B\u00f8rn af \u00e6ldre f\u00e6dre har sandsynligvis flere genetiske mutationer end dem, der er f\u00f8dt af yngre f\u00e6dre.<\/p>\n

Mens de fleste af disse mutationer er harml\u00f8se, kan nogle have alvorlige konsekvenser. De kan bidrage til genetiske sygdomme, der rammer omkring \u00e9n ud af 300 levendef\u00f8dte. Disse \"de novo\"-mutationer er ansvarlige for forskellige lidelser, herunder akondroplasi og Apert syndrom.<\/p>\n

Desuden kan de aldersrelaterede \u00e6ndringer i epigenetiske m\u00e6rker, der findes p\u00e5 DNA i menneskes\u00e6d, spille en rolle. Disse epigenetiske m\u00e6rker kontrollerer genekspressionen og kan \u00e6ndres p\u00e5 grund af forskellige milj\u00f8faktorer. Disse \u00e6ndringer er ikke kun relateret til s\u00e6dudviklingen, men er ogs\u00e5 forbundet med neuroudviklingen, selvom de n\u00f8jagtige \u00e5rsager stadig er uklare.<\/p>\n

 <\/p>\n

Faderens alder og behovet for bevidsthed<\/h2>\n

Det er tydeligt, at Faderens alder betyder noget<\/a>Flere og flere m\u00e6nd bliver f\u00e6dre i en \u00e6ldre alder. En kombination af faktorer, herunder forsinkede \u00e6gteskaber, andet \u00e6gteskab, assisteret reproduktion og \u00e6ndrede samfundsnormer, har f\u00f8rt til, at flere m\u00e6nd bliver \u00e6ldre f\u00e6dre. Men som vi har set, er det ikke uden konsekvenser.<\/p>\n

I dette landskab har virksomheder som ExSeed introduceret innovative l\u00f8sninger, der hj\u00e6lper m\u00e6nd med at vurdere og overv\u00e5ge deres fertilitet bekvemt hjemmefra. Den ExSeed s\u00e6dpr\u00f8ve i hjemmet<\/a>sammen med en smartphone-app giver m\u00e6nd mulighed for at m\u00e5le deres s\u00e6ds bev\u00e6gelighed, koncentration og generelle kvalitet, alt sammen hjemme hos dem selv. Det giver m\u00e6nd mulighed for at tage kontrol over deres reproduktive sundhed.<\/p>","protected":false},"excerpt":{"rendered":"

When we think of the effects of age on fertility, our minds often gravitate towards women, focusing on the declining egg supply, chromosomal issues, and infertility. One study even found that 1 in 5 men consider infertility to be only a woman’s issue. But here’s something that’s not talked about as often \u2013 the impact […]<\/p>\n","protected":false},"author":3,"featured_media":126791,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[198,201],"tags":[],"class_list":["post-120937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mens-fertility","category-mind-body"],"acf":[],"yoast_head":"\nDo Men Have Biological Clocks? Male Fertility and Age<\/title>\n<meta name=\"description\" content=\"Age and fertility are often discussed in relation to women and those with wombs, but men and people producing sperm are not immune from time.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.exseedhealth.com\/da\/mens-biological-clock\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Do Men Have Biological Clocks? Male Fertility and Age\" \/>\n<meta property=\"og:description\" content=\"Age and fertility are often discussed in relation to women and those with wombs, but men and people producing sperm are not immune from time.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.exseedhealth.com\/da\/mens-biological-clock\/\" \/>\n<meta property=\"og:site_name\" content=\"ExSeed Health\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ExSeedHealth\" \/>\n<meta property=\"article:published_time\" content=\"2023-10-21T09:55:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-20T16:06:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.exseedhealth.com\/wp-content\/uploads\/2023\/10\/Blog-Image-Upload-Size-1920x1080-97.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Emil Andersen, PhD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:site\" content=\"@ExSeed_Health\" \/>\n<meta name=\"twitter:label1\" content=\"Skrevet af\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emil Andersen, PhD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimeret l\u00e6setid\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/mens-biological-clock\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/mens-biological-clock\\\/\"},\"author\":{\"name\":\"Emil Andersen, PhD\",\"@id\":\"https:\\\/\\\/www.exseedhealth.com\\\/#\\\/schema\\\/person\\\/5d08eb43d90734a01dcf3cb77ce5e109\"},\"headline\":\"Do Men Have Biological Clocks? 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Han er kendt for at v\u00e6re hovedforfatter til den hidtil mest omfattende unders\u00f8gelse af v\u00e6gttabs indvirkning p\u00e5 s\u00e6dkvaliteten. Under sin ans\u00e6ttelse p\u00e5 University of Cambridge stod Emil i spidsen for innovativ forskning med fokus p\u00e5 at dechifrere de grundl\u00e6ggende mekanismer i s\u00e6dceller og udvikle metoder til at vurdere deres fertilitetspotentiale. 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